This category contains neuroendocrine peptides and hormones that engage the hypothalamic-pituitary-gonadal axis and central melanocortin pathways to modulate reproductive function and arousal.

The products in this category target the central nervous system and gonadal tissues to influence sexual and reproductive physiology. PT-141 and Melanotan II act centrally at MC3R and MC4R receptors in the hypothalamus to modulate sexual desire and arousal, distinct from peripheral vascular mechanisms. Kisspeptin-10 serves as the master upstream regulator of the HPG axis, triggering pulsatile GnRH release. Human chorionic gonadotropin (HCG) binds the LH receptor on gonadal cells to stimulate endogenous testosterone and estrogen synthesis, supporting comprehensive reproductive endocrinology.